Endocrine Abstracts

The Androgen Receptor (AR) is a ligand dependent transcription factor that regulates the development and maintenance of the male reproductive system. Previous studies in AIS have demonstrated ligand binding domain mutations resulting in decreased trans-activation activity through reduced N-terminal/C-terminal interaction of the AR, despite unaltered ligand binding ability.We have introduced mutations in the hinge region of the Androgen Receptor (AR) and assessed the effect...